Welcome to The Spencer Lab

The Spencer Lab is in the Section of Stem Cell Biology in the Division of Oncology in the Department of Medine at Washington University School of Medicine in St. Louis.

Human Genome Research in the Spencer lab is a combination of experimental and computational science that is focused on the common theme of the genetics, genomics, and epigenetics of acute myeloid leukemia. We have specific expertise in DNA methylation, 3D genome architecture, and HOX gene expression and regulation in AML, although we are broadly interested in epigenetics and gene regulation in cancer. We also have extensive experience using genomic technologies to make observations in primary human samples to understand fundamental mechanisms of cancer genomics.

We use a range of experimental systems and techniques in our lab, including:

  • Whole-exome sequencing, whole-genome sequencing, error-corrected amplicon sequencing
  • Long read sequencing using Oxford Nanopore and PacBio Hifi platforms
  • ChIP-seq, RNA-seq, ATAC-seq, CUT&Run, CUT&Tag
  • in situ HiC, capture-C, HiChIP, PLAC-seq
  • Whole-genome bisulfite sequencing
  • CRISPR/Cas9 genome editing, CRISPRi epigenetic editing
  • CRE-seq massively parallel reporter assays
  • Single cell technologies
  • Human cell lines, human pluripotent stem cells, including NIH-approved embryonic stem cells and induced pluripotent stem (iPS) cells.
  • Primary human AML samples
  • Mouse models HOXA locus

We currently have open positions for PhD students and Postdocs to join the team (more info) !